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läste en notis om sötningsmedel i tidningen i morse..(Borås tidning)
de stod så här
Sötningsmedel ger cancer.
Det konstgjorda sötningsmedlet aspartam ökar kraftigt risken för en rad olika former av cancer hos råttor, visar en ny studie av italienska forskare (Science Daily 060213). Aspartam är ett av de vanligaste sötningsmedlen och används i produkter som läsk, tuggumi, snask, bakverk, yoghurt, halstabletter och vitaminpiller. Enligt forskarna ökade frekvensen av blod-och lymfcancer markant hos råttorna redan vid en daglig dos på 20 milligram aspartam per kilo kroppsvikt. Den högsta rekomenderade dagliga dosen för människor är förnärvarande betydligt högre : 50mg/kg i USA och 40mg/kg i EU. (TT)låter ju inte alls bra..
är de någon som vet något mer om denna studie??Det är inget att bry sig om. Det finns hur många studier som helst (Grub?) som visar att det inte är någon fara med cancerrisken. Råttorna får kanske passa sig, dock.
ettan wrote:låter ju inte alls bra.. är de någon som vet något mer om denna studie??[http://www.wnho.net/aspartame_study_14july2005.pdf]
SLV:s artikel som säger att ADI är säkert, skrevs 1998 men både artikeln och ADI:t i fråga baseras helt på djurstudier från 70- och 80-tal. Studierna som visar på signifikanta bieffekter började dyka upp på 2000-talet.
Det finns inga klara bevis för att aspartam skulle vara cancerframkallande hos människa.
Men visst verkar det finnas otrevliga bieffekter. Oklarheten är nog det mest oroväckande.
J Pharmacol Sci. 2003 Jan;91(1):83-6. Formaldehyde-induced shrinkage of rat thymocytes.
”To test the possibility that micromolar formaldehyde, a metabolite of methanol derived from aspartame, exerts cytotoxicity, its effect on rat thymocytes was examined under the in vitro condition using a flow cytometer. Incubation of thymocytes with formaldehyde at 100 micro M or more for 24 h significantly increased the populations of shrunken cells and cells with hypodiploid DNA. The peak blood concentration of methanol in human subjects administered abuse doses of aspartame has been reported to exceed 2 mg/dL (625 micro M). It would increase the population of thymocytes undergoing apoptosis if formaldehyde at 100 micro M or more appears in the blood after administration of aspartame.”
Life Sci. 1998;63(5):337-49. Formaldehyde derived from dietary aspartame binds to tissue components in vivo.
”Adult male rats were given an oral dose of 10 mg/kg aspartame 14C-labelled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (>98% in plasma, >75% in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of 1-2% of total radioactivity administered per g or mL, changing little with time. Other organs (brown and white adipose tissues, muscle, brain, cornea and retina) contained levels of label in the range of 1/12 to 1/10th of that of liver. In all, the rat retained, 6 hours after administration about 5% of the label, half of it in the liver. The specific radioactivity of tissue protein, RNA and DNA was quite uniform. The protein label was concentrated in amino acids, different from methionine, and largely coincident with the result of protein exposure to labelled formaldehyde. DNA radioactivity was essentially in a single different adduct base, different from the normal bases present in DNA. The nature of the tissue label accumulated was, thus, a direct consequence of formaldehyde binding to tissue structures. The administration of labelled aspartame to a group of cirrhotic rats resulted in comparable label retention by tissue components, which suggests that liver function (or its defect) has little effect on formaldehyde formation from aspartame and binding to biological components. The chronic treatment of a series of rats with 200 mg/kg of non-labelled aspartame during 10 days resulted in the accumulation of even more label when given the radioactive bolus, suggesting that the amount of formaldehyde adducts coming from aspartame in tissue proteins and nucleic acids may be cumulative. It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.”
Pharmacol Biochem Behav. 2004 May;78(1):121-7. Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats.
”This study demonstrated that chronic aspartame consumption in rats can lead to altered T-maze performance and increased muscarinic cholinergic receptor densities in certain brain regions. Control and treated rats were trained in a T-maze to a particular side and then periodically tested to see how well they retained the learned response. Rats that had received aspartame (250 mg/kg/day) in the drinking water for 3 or 4 months showed a significant increase in time to reach the reward in the T-maze, suggesting a possible effect on memory due to the artificial sweetener. Using [(3)H]quinuclidinyl benzilate (QNB) (1 nM) to label muscarinic cholinergic receptors and atropine (10(-6) M) to determine nonspecific binding in whole-brain preparations, aspartame-treated rats showed a 31% increase in receptor numbers when compared to controls. In aspartame-treated rats, there was a significant increase in muscarinic receptor densities in the frontal cortex, midcortex, posterior cortex, hippocampus, hypothalamus and cerebellum of 80%, 60%, 61%, 65%, 66% and 60%, respectively. The midbrain was the only area where preparations from aspartame-treated rats showed a significant increase in Na(+),K(+)-ATPase activity. It can be concluded from these data that long-term consumption of aspartame can affect T-maze performance in rats and alter receptor densities or enzymes in brain.”
Toxicol Sci. 2005 Dec 13; Synergistic Interactions Between Commonly Used Food Additives in a Developmental Neurotoxicity Test.
”Exposure to non-nutritional food additives during the critical development window has been implicated in the induction and severity of behavioural disorders such as attention deficit hyperactivity disorder (ADHD). Although the use of single food additives at their regulated concentrations is believed to be relatively safe in terms of neuronal development, their combined effects remain unclear. We therefore examined the neurotoxic effects of four common food additives in combinations of two (Brilliant Blue and L-glutamic acid, Quinoline Yellow and aspartame) to assess potential interactions. Mouse NB2a neuroblastoma cells were induced to differentiate and grow neurites in the presence of additives. After 24 h, cells were fixed and stained and neurite length measured by light microscopy with computerised image analysis. Neurotoxicity was measured as an inhibition of neurite outgrowth. Two independent models were used to analyse combination effects: effect additivity and dose additivity. Significant synergy was observed between combinations of Brilliant Blue with L-glutamic acid, and Quinoline Yellow with aspartame, in both models. Involvement of N-methyl-D-aspartate (NMDA) receptors in food additive-induced neurite inhibition was assessed with a NMDA antagonist, CNS-1102. L-glutamic acid- and aspartame-induced neurotoxicity was reduced in the presence of CNS-1102; however the antagonist did not prevent food colour-induced neurotoxicity. Theoretical exposure to additives was calculated based on analysis of content in foodstuff, and estimated percentage absorption from the gut. Inhibition of neurite outgrowth was found at concentrations of additives theoretically achievable in plasma by ingestion of a typical snack and drink. In addition, Trypan Blue dye exclusion was used to evaluate the cellular toxicity of food additives on cell viability of NB2a cells; both combinations had a straightforward additive effect on cytotoxicity. These data have implications for the cellular effects of common chemical entities ingested individually and in combination.”
Det är formaldehyd som ligger bakom cancerrisken, och formaldehyd bildas vid metaboliseringen av aspartam, och formaldehyd är bevisat cancerogent, både hos djur och människa.
”After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, ”strong but not sufficient” evidence of leukemia, and limited evidence of sinonasal cancer.”
Environ Health Perspect. 2005 Sep;113(9):1205-8.
”The administration of labelled aspartame to a group of cirrhotic rats resulted in comparable label retention by tissue components, which suggests that liver function (or its defect) has little effect on formaldehyde formation from aspartame and binding to biological components. The chronic treatment of a series of rats with 200 mg/kg of non-labelled aspartame during 10 days resulted in the accumulation of even more label when given the radioactive bolus, suggesting that the amount of formaldehyde adducts coming from aspartame in tissue proteins and nucleic acids may be cumulative. It is concluded that aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.”
Life Sci. 1998;63(5):337-49.
Acesulfam-K, som tillsätts tillsammans med aspartam, har kromosomförändrande egenskaper:
”Acesulfame-K, a sweetening agent, was evaluated in vivo for its genotoxic and clastogenic potentials. Swiss albino male mice were exposed to the compound by gavage. Bone marrow cells isolated from femora were analysed for chromosome aberrations. Doses of 15, 30, 60, 450, 1500 and 2250 mg of acesulfame-K/kg body weight induced a positive dose-dependent significant clastogenicity. These doses were within the no-toxic-effect levels reported by the Joint Expert Committee for Food Additives of the World Health Organization and the Food and Agriculture Organization of the United Nations. In view of the present significant in vivo mammalian genotoxicity data, acesulfame-K should be used with caution.”
Food Chem Toxicol. 1997 Dec;35(12):1177-9.
ettan wrote:läste en notis om sötningsmedel i tidningen i morse..(Borås tidning)de stod så här
Sötningsmedel ger cancer.
Det konstgjorda sötningsmedlet aspartam ökar kraftigt risken för en rad olika former av cancer hos råttor, visar en ny studie av italienska forskare (Science Daily 060213). Aspartam är ett av de vanligaste sötningsmedlen och används i produkter som läsk, tuggumi, snask, bakverk, yoghurt, halstabletter och vitaminpiller. Enligt forskarna ökade frekvensen av blod-och lymfcancer markant hos råttorna redan vid en daglig dos på 20 milligram aspartam per kilo kroppsvikt. Den högsta rekomenderade dagliga dosen för människor är förnärvarande betydligt högre : 50mg/kg i USA och 40mg/kg i EU. (TT)låter ju inte alls bra..
är de någon som vet något mer om denna studie??Vissa började dricka ”ett nytt vatten” som heter Blue Keld och enligt ”vår egen expert på TV3” Anna Skipper är inte detta vatten så hälsosamt för hon tala om att just Aspartam ökade risken för en sämre hälsa.
vem bryr sig egentligen om ”ökar risken” för cancer? cigg osv ger cancer men bara vissa som får det ändå. många rökare som dör i förtid men desto fler som lever länge. orka bry sig om risken att dö hela tiden? om sötningsmedel är så hemskt drick vanlig läsk då men se i stället hur du ser ut efter ett tag och se om liver är så kul att leva ens då.
finns bara en ”fiende”bland mat det är fruktosen i vanligt socker.finns bara en ”fiende”bland mat det är fruktosen i vanligt socker.[/QUOTE]
Det finns mkt mkt fler ”fiender” än fruktos.
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